| Product Name | TGFβ RIII Antibody (H-280) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 511-790 mapping near the C-terminus of TGFβ RIII of human origin |
| Modification Notes | A total of three members of the TGF∫ family, TGF∫1, TGF∫2 and TGF∫3, have been identified in mammals (1–3). Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization (2,3). TGF∫s mediate their activity by high affinity binding to the type II receptor transmembrane protein with a cytoplasmic serine-threonine kinase domain (4–6). TGF∫ RIII (transforming growth factor beta receptor type 3), also known as TGFBR3 or TGFR-3, is an 850 amino acid secreted and single-pass type I membrane protein that contains one ZP domain and may assist in capturing TGF∫ for presentation to signaling receptors. TGF∫ RIII undergoes post-translational modification by glycosaminoglycan groups (GAG) and is encoded by a gene that maps to human chromosome 1p22.2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TGFβ RIII of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 511-790 mapping near the C-terminus of TGF&beta RIII of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 511-790 mapping near the C-terminus of TGFβ RIII of human origin |
| Entrez Gene | 7049 |
|---|
| Application Notes | recommended for detection of TGFβ RIII of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
