| Product Name | LOXL3 Antibody (H-70) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 111-180 mapping near the N-terminus of LOXL3 of human origin |
| Modification Notes | Lysyl oxidase (LOX) proteins belong to a family of enzymes that oxidize primary amine substrated to reactive aldehydes. In fibrillar collagens and elastin, LOX catalyzes the lysine-derived cross-links of collagen fibrils and insoluble elastic fibers in the extracellular matrix. It can localize both to the nucleus and the cytoplasm. LOX is involved in tumor suppression, cell motility, cellular senescence and developmental regulation. There are four homologs of LOX, lysyl oxidase-like proteins, designated LOX-like (LOXL1-LOXL4) proteins. LOXL3 is an extracellular protein that localizes specifically to sites of elastogenesis. LOXL2 and LOXL3 can interact and cooperate with the Snail protein to downregulate E-cadherin expression. In epithelial cells, overexpression of LOXL2 or LOXL3 may induce an epithelial-mesenchymal transitions process, an important element in tumor progression. LOXL3 is a widely expressed protein with highest levels of expression in placenta, small intestine, testis, heart, ovary and spleen. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of LOXL3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 111-180 mapping near the N-terminus of LOXL3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 111-180 mapping near the N-terminus of LOXL3 of human origin |
| Entrez Gene | 84695 |
|---|
| Application Notes | recommended for detection of LOXL3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
