Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human blood vessels showing plasma staining.Application
Western blot analysis of Protein S expression in non-transfected: (A) and human Protein S transfected: (B) 293 whole cell lysates.| Product Name | Protein S Antibody (H-90) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 81-170 of Protein S of human origin |
| Modification Notes | Protein S (PROS) is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated protein C (APC) and facilitates clearance of early apoptotic cells. In the plasma, circulating Protein S becomes inactive upon complexing with C4b-binding protein (C4BP); 60-70% of Protein S circulates in complex with C4BP. Calcium-dependent association of C4BP-Protein S with apoptotic cells influences the regulation of complement activation. Protein S has APC-independent anticoagulant activity through direct inhibition of prothrombin activation via interactions with Factor X A, Factor V A and phospholipids. Autosomal dominant Protein S deficiency (levels 15 to 37% of normal) correlates with severe recurrent venous thrombosis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of Protein S of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 81-170 of Protein S of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 81-170 of Protein S of human origin |
| Entrez Gene | 5627 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human blood vessels showing plasma staining.
Application
Western blot analysis of Protein S expression in non-transfected: (A) and human Protein S transfected: (B) 293 whole cell lysates.| Application Notes | recommended for detection of Protein S of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
