Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These enzymes differ in their tissue distributions and substrate specificities, although the gene structure (number and length of exons) is similar among family members. UST (Uronyl 2-sulfotransferase), also known as DS2ST or 2OST, is a 406 amino acid member of the sulfotransferase 3 family. Localized to the golgi apparatus membrane, UST is a sulfotransferase that catalyzes the transfer of sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues of chondroitin sulfate. While UST has high activity with the aforementioned residues, it has no activity with desulfated N-resulfated heparin. UST is a single-pass type II membrane protein.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFIHCELISA
recommended for detection of UST of mouse, rat, human and canine origin by WB, IP, IF, IHC(P) and ELISA: