| Product Name | Antiquitin Antibody (H-149) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 391-539 mapping at the C-terminus of Antiquitin of human origin |
| Modification Notes | Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. Antiquitin, also known as ALDH7A1 (aldehyde dehydrogenase 7 family, member A1), ATQ1, EPD or PDE, is a 539 amino acid protein that is highly expressed in ovary, heart, eye, kidney and ear tissue and plays an important role in the detoxification of lipid peroxidation- and alcohol metabolism-related aldehydes. Mutations in the gene encoding Antiquitin are the cause of pyridoxine-dependent epilepsy (PDE), a rare disorder that is characterized by seizures that begin at infancy and involve muscle rigidity, convulsions and loss of consciousness. Additionally, PDE is associated with poor muscle tone, hypothermia and irritability. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Antiquitin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 391-539 mapping at the C-terminus of Antiquitin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 391-539 mapping at the C-terminus of Antiquitin of human origin |
| Entrez Gene | 501 |
|---|
| Application Notes | recommended for detection of Antiquitin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
