| Product Name | Otospiralin Antibody (M-89) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-89 representing full length Otospiralin of mouse origin |
| Modification Notes | Otospiralin is an 89 amino acid inner ear-specific protein ecoded by the OTOS gene. Otospiralin is synthesized by fibrocytes of spiral limbus and spiral ligament in the cochlea. Fibrocytes are responsible for maintaining inner ear homeostasis and impairment or alteration of these cells may lead to deterioration of auditory function. Degeneration of fibrocytes due to the absence of Otospiralin leads to irreversible deafness in guinea pigs and moderate deafness in mice. Loss of function in hair cells of the inner ear may also be caused by the downregulation of Otospiralin. Otospiralin is conserved from fish to mammals. It shares homology with gag p30 core shell and SARS of type C retroviruses. One isoform is produced due to alternative splicing. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Otospiralin of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-89 representing full length Otospiralin of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-89 representing full length Otospiralin of mouse origin |
| Entrez Gene | 150677 |
|---|
| Application Notes | recommended for detection of Otospiralin of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
