| Modification Notes |
Integrin a9 (Integrin aRLC) is a 1,035 amino acid protein encoded by the human gene ITGA9. Integrin a9 belongs to the integrin alpha chain family and contains seven FG-GAP repeats. Integrins are a large family of cell surface glycoproteins that mediate cell-cell adhesion and cell-matrix adhesion. They are heterodimers composed of an å and a ∫ subunit bound noncovalently to each other. The å subunits contain a large N-terminal extracellular domain with seven conserved repeats of putative metal binding domains, a transmembrane segment, and a short C-terminal cytoplasmic tail. Integrin a9 is single-pass type I membrane protein found in airway epithelium, the basal layer of squamous epithelium, smooth muscle, skeletal muscle, and hepatocytes as a heterodimer of an å and a ∫ subunit. |