Application
Western blot analysis of Properdin expression in non-transfected 293T: (A), human Properdin transfected 293T: (B) and human PBL (C) whole cell lysates.| Product Name | Properdin Antibody (H-181) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The serum complement system (SCS), containing over 30 glycoproteins, influences physiological mechanisms of the body in response to immune complex (the classical pathway), carbohydrate (the lectin pathway) or bacterial (alternative pathway) initiation. Properdin, also known as complement factor P (CFP), PFC, BFP or PFD, is a secreted glycoprotein that participates in positively regulating the alternative pathway of the SCS. Properdin exists as a cyclic polymer with six Thrombospondin type-1 domains and binds to C3 and C5 convertase complexes (C3bBb and (C3b)nBb) functioning to assist in their stabilization. Properdin is also required for the deposition of C3b onto the surface of pathogens. Mutations in the gene encoding Properdin can result in Properdin deficiency (PFD), a disease characterized by higher susceptibility to bacterial infections. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Properdin of mouse, human and, to a lesser extent, rat origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 289-469 mapping at the C-terminus of Properdin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 289-469 mapping at the C-terminus of Properdin of human origin |
| Entrez Gene | 5199 |
|---|
Application
Western blot analysis of Properdin expression in non-transfected 293T: (A), human Properdin transfected 293T: (B) and human PBL (C) whole cell lysates.| Application Notes | recommended for detection of Properdin of mouse, human and, to a lesser extent, rat origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
