Mouse major urinary proteins, known as MUPs, are pheromone-binding proteins that are excreted in the urine where they influence mouse physiology and behavior. MUP mRNAs are present in the liver and several secretory tissues including lachrymal, submaxillary and mammary tissues. MUP proteins are the products of a multi-gene family that exhibit diverse tissue specific, developmental and hormonal controls. Several MUP protein isoforms exist and are expressed and secreted by sexually mature male mice. The broad chemical class of pheromones that bind to MUPs are believed to be accommodated within a b-barrel motif. Testosterone treatment influences the MUP phenotype by increasing MUP excretion and altering the relative proportions of each isoform. As an androgen-dependent protein present in adult male urine, MUP may influence olfactory cues through mediating differential pheromone- binding profiles.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of a broad range of MUP isoforms of rat origin by WB, IP, IF and ELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 1-181 representing full length MUP of rat origin
Tissue Specificity
epitope corresponding to amino acids 1-181 representing full length MUP of rat origin
Application
Application
Western blot analysis of MUP expression in rat liver tissue extract.
Application Notes
recommended for detection of a broad range of MUP isoforms of rat origin by WB, IP, IF and ELISA
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.