Mono-ADP-ribosylation is one of the posttranslational protein modifications regulating cellular metabolism, e.g. nitrogen fixation, in prokaryotes. Mono-ADP-ribosylation is a posttranslational modification of proteins in which the ADP-ribose moiety of nicotinamide adenine dinucleotide is transferred to an acceptor amino acid. Five mammalian ADP-ribosyltransferases (ART1-ART5) have been cloned, and expression is restricted to tissues such as cardiac and skeletal muscle, leukocytes, brain and testis. ART1 and ART2 are glycosyl-phosphatidylinositol (GPI)-anchored ectoenzymes expressed at the cell surface of rat and mouse T lymphocytes. ART1 is a protein that is expressed in human skeletal muscle. In skeletal muscle and lymphocytes, ART1 modifies specific members of the Integrin family of adhesion molecules, suggesting that ADP-ribosylation affects cell-matrix or cell-cell interactions.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of ART2 of mouse and rat origin by WB, IP, IF and ELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 41-130 mapping near the N-terminus of ART2 of mouse origin
Tissue Specificity
epitope corresponding to amino acids 41-130 mapping near the N-terminus of ART2 of mouse origin