| Product Name | xCT Antibody (H-121) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | xCT, also known as SLC7A11 (solute carrier family 7, (cationic amino acid transporter, y+ system) member 11) or CCBR1, is a 501 amino acid multi-pass membrane protein that belongs to the polyamine-organocation superfamily of amino acid transporters. Existing as a disulfide-linked heterodimer with CD98, xCT functions as a member of a heteromeric Na(+)-independent anionic amino acid transport system that specifically facilitates the exchange of anionic amino acids for anionic forms of cystine and glutamate, thereby mediating the formation of glutathione within the cell. Due to its involvement in amino acid transport, xCT is associated with the pathogenesis of glioma-induced neurodegeneration and brain edema, as well as pancreatic cancer. The gene encoding xCT maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of xCT of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 134-249 mapping within an internal region of xCT of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 134-249 mapping within an internal region of xCT of human origin |
| Entrez Gene | 23657 |
|---|
| Application Notes | recommended for detection of xCT of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
