Application
Western blot analysis of Cbp expression in non-transfected: (A) and human Cbp transfected: (B) 293T whole cell lysates.Application
Western blot analysis of Cbp expression in non-transfected: (A) and human Cbp transfected: (B) 293T whole cell lysates.Application
Western blot analysis of Cbp expression in M1 whole cell lysate.| Product Name | Cbp Antibody (H-100) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The Src family of protein tyrosine kinases (Src-PTKs) is important in the regulation of growth and differentiation of eukaryotic cells. The activity of Src-PTKs in cells of different types is negatively controlled by Csk. Csk binding protein (Cbp), also designated phosphoprotein associated with glycosphingo-lipid-enriched microdomains (GEMs) or PAG, is a ubiquitously expressed transmembrane phosphoprotein that binds specifically to the SH2 domain of Csk. Cbp is involved in the membrane localization of Csk and in Csk-mediated inhibition of c-Src. In the plasma membrane, Cbp is exclusively localized in the GM1 ganglioside-enriched detergent-insoluble membrane domain, which is important in receptor-mediated signaling. Cbp is a component of the regulatory mechanism controlling the activity of membrane-associated Src-PTKs. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Cbp of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 333-432 mapping at the C-terminus of Cbp of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 333-432 mapping at the C-terminus of Cbp of human origin |
| Entrez Gene | 55824 |
|---|
Application
Western blot analysis of Cbp expression in non-transfected: (A) and human Cbp transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of Cbp expression in non-transfected: (A) and human Cbp transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of Cbp expression in M1 whole cell lysate.| Application Notes | recommended for detection of Cbp of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
