| Product Name | Stim2 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Ca2+ influx is essential for a variety of cellular functions, such as secretion and transcription. Stim1 (stromal interaction molecule 1) is a ubiquitously expressed cell surface transmembrane glycoprotein that plays a role in mediating Ca2+ influx following the depletion of intracellular Ca2+ stores. Stim1 functions in the endoplasmic reticulum (ER) where it acts as a Ca2+ sensor via its EF-hand domain and is capable of causing large conformational changes in response to varying Ca2+ levels. When Ca2+ levels drop, Stim1 translocates from the ER to the plasma membrane, where it activates the Ca2+ release-activated Ca2+ (CRAC) channel subunit, Orai1. Stim2 (stromal interaction molecule 2) is a 746 amino acid protein that contains one EF-hand domain and one SAM domain and localizes to the ER as a single-pass type I membrane protein. Stim2 exists as an oligomer with Stim1 and plays an essential role in the inhibition of Stim1-mediated Ca2+ influx. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Stromal interaction molecule 2 precursor of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 447-746 mapping at the C-terminus of Stim2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 447-746 mapping at the C-terminus of Stim2 of human origin |
| Entrez Gene | 57620 |
|---|
| Application Notes | recommended for detection of Stromal interaction molecule 2 precursor of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
