Application
Western blot analysis of GHS-R1 expression in rat hypothalamus tissue extract.| Product Name | GHS-R1 Antibody (H-80) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | GHS-R1 (growth hormone secretagogue receptor type 1) is a G protein-coupled receptor. GHS-R1 binds synthetic peptidyl and nonpeptidyl growth hormone secretagogues (GHS), which stimulate growth hormone (GH) release. The binding of GHS to GHS-R1 is magnesium-dependent, inhibited by GTP-g-S and not displaced by the two hypothalamic hormones, growth hormone releasing hormone (GHRH) and somatostatin. This suggests that the interaction between GHS and GHS-R1 is distinct from GH regulation via GHRH and somatostatin and there exists a natural growth hormone regulator specific for GHS-R. GHS-R1 is primarily expressed in the hypothalamus and pituitary, and expression has been shown to be elevated in pituitary adenoma tissue. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of GHS-R1&alpha and GHS-R1&beta of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 186-265 mapping within an internal region of GHS-R1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 186-265 mapping within an internal region of GHS-R1 of human origin |
| Entrez Gene | 2693 |
|---|
Application
Western blot analysis of GHS-R1 expression in rat hypothalamus tissue extract.| Application Notes | recommended for detection of GHS-R1&alpha and GHS-R1&beta of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
