The anterior pituitary secretes a variety of hormones that are involved in cell growth, differentiation and development. Prolactin, a 226 amino acid protein, plays a role in multiple processes, including cell growth, reproduction and immune function. Full-length Prolactin, as well as an alternative splice product lacking the third exon, are secreted by endothelial cells involved in angiogenesis. In addition to its role in mammary developmant and lactation, Prolactin is known to play a role in the development of mammary cancer, acting as both a mitogen and a differentiating agent. Prolactin has also been shown to enhance the proliferation of B cell hybridomas, leading to an overall increase in antibody production. In addition, Prolactin has been demonstrated to reverse the antiproliferative effects of the immunosuppressive cytokine TGF-beta. Prolactin is also associated with a variety of autoimmune diseases, including arthritis and type 1 diabetes.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of Prolactin of human origin by WB, IP, IF and ELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 96-200 of Prolactin of human origin
Tissue Specificity
epitope corresponding to amino acids 96-200 of Prolactin of human origin