| Product Name | TBX5 Antibody (H-70) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Members of the T-box (Tbx) gene family share a conserved domain that codes for the T-box, a sequence involved in DNA-binding and protein dimerization. The Tbx gene family is largely conserved throughout metazoan evolution, and is implicated in a variety of developmental processes ranging from the formation of germ layers to the organizational patterning of the central nervous system. Embryonic expression of TBX5 has been found in the human retina. TBX5 as well as TBX20 are required for and have non-redundant functions in early heart development. The genes encoding human TBX5 and TBX1 are mutated in cardiac congenital anomaly syndromes. Specifically, mutations in the TBX5 gene have been identified in patients with Holt-Oram syndrome, an autosomal dominant heart-hand syndrome characterized by congenital heart disease and upper limb deformity. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISAGSChIP |
| recommended for detection of TBX5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 258-327 mapping within an internal region of TBX5 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 258-327 mapping within an internal region of TBX5 of human origin |
| Entrez Gene | 6910 |
|---|
| Application Notes | recommended for detection of TBX5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
