| Product Name | ADAMTS-4 Antibody (H-74) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | ADAMTS (a disintegrin and metalloprotease with Thrombospondin motifs) protein family members contain an N-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain, and a C-terminus that contains a varying number of thrombospondin type-1 (TSP-1) motifs. ADAMTS-4 (also known as aggrecanase-1) is an 837 amino acid, Zn-metalloprotease that mediates proteolytic degradation of Aggrecan, a major component of cartilage. Aggrecan swells and hydrates the collagen fibril meshwork in cartilage, which confers compressibility and resilience. Degradation of Aggrecan is a factor that contributes to erosion of articular cartilage in arthritic diseases. Traditional matrix metalloproteinases (MMPs) cleave Aggrecan at Asn 341-Phe 342 whereas ADAMTS-4 cleaves at Glu 373-Ala 374. Inhibitors tailored to both MMPs and ADAMTSs may hinder the rate of cartilage degradation in arthritic individuals. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ADAMTS-4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 764-837 mapping at the C-terminus of ADAMTS-4 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 764-837 mapping at the C-terminus of ADAMTS-4 of human origin |
| Entrez Gene | 9507 |
|---|
| Application Notes | recommended for detection of ADAMTS-4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
