| Product Name | HCP1 Antibody (H-197) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | HCP1 (Heme carrier protein 1), also known as proton-coupled folate transporter (PCFT), is a multi-pass transmembrane protein that is expressed in the small intestine. It is predominantly found in the duodenum and the jejunum localizing to the apical brush border. HCP1 is required for normal folate absorption in the intestine and is associated with folate homeostasis. HCP1 mediates the transport of folate and functions most optimally at a low extracellular pH of approximately 5.5. HCP1 functions independently of Na+ and is insensitive to membrane potential. It exhibits high affinity for folic acid and low affinity for the PT523 antifolate. HCP1 is post-translationally regulated by iron levels in the duodenum. During iron deficiency, HCP1 localizes to the apical membrane; however, iron excess causes HCP1 to localize in the cytoplasm. Sulfasalazine is a potent inhibitor of HCP1. Mutations in the gene encoding HCP1 can result in the autosomal recessive disorder hereditary folate malabsorption (HFM). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of heme carrier protein 1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 232-297 mapping within an internal region of HCP1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 232-297 mapping within an internal region of HCP1 of human origin |
| Entrez Gene | 113235 |
|---|
| Application Notes | recommended for detection of heme carrier protein 1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
