Synaptonemal complexes are meiosis-specific nuclear organelles that are involved in chromosome rearrangements, such as chromosome pairing and recombination during meiotic prophase. SCP-2 and SCP-3 are major components of the lateral elements of synaptonemal complexes. SCP-3 is a sister chromatid arm cohesin during mammalian meiosis I. It has a C-terminal coiled-coil domain that promotes homotypic interactions in vitro. SCP-3 is expressed in testicular meiotic prophase cells and primordial germ cells. SCP-2 and SCP-3 first appear in leptotene-stage spermatocytes and disappear in late meiotic cells.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFIHCELISA
recommended for detection of SCP-3 of mouse and rat origin by WB, IP, IF, IHC(P) and ELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 1-254 representing full length SCP-3 of mouse origin
Tissue Specificity
epitope corresponding to amino acids 1-254 representing full length SCP-3 of mouse origin