| Product Name | PUS1 Antibody (H-280) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | PUS1 (Psuedouridine synthase 1) belongs to the tRNA pseudouridine synthase truA family. PUS1 functions in the conversion of uridine into pseudouridine after the nucleotide has been incorporated into RNA. It may have a functional role in tRNAs and is also thought to assist in the peptidyl transfer reaction of rRNAs. As a nucleus-resident protein, PUS1 forms a complex with RARG and the SRA1 RNA. PUS1 is widely expressed, with highest levels of expression in the brain and skeletal muscle tissues. Defects in PUS1 are a cause of myopathy with lactic acidosis and sideroblastic anemia (MLASA), also known as mitochondrial myopathy and sideroblastic anemia. MLASA is a rare autosomal recessive oxidative phosphorylation disorder specific to bone marrow and skeletal muscle. The deduced human PUS1 protein contains 348 amino acids and shares 92% sequence homology with mouse PUS1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PUS1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 148-427 mapping at the C-terminus of PUS1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 148-427 mapping at the C-terminus of PUS1 of human origin |
| Entrez Gene | 80324 |
|---|
| Application Notes | recommended for detection of PUS1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
