| Product Name | SLU7 Antibody (H-180) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | In order to produce correctly spliced messenger RNA, two catalytic splicing steps are required (1-3). After catalytic step I, a major remodeling of the spliceosome occurs to establish the active site for step II (4). During the second step of mRNA splicing, exon 1 attacks an adenine-guanine (AG) dinucleotide at the 3’ splice site. SLU7, the human homolog of the yeast step II splice factor Slu7, is required for selection of the correct AG (1,4,5). Human SLU7 associates with the spliceosome late in the splicing pathway prior to recognition of the 3’ splice site for step II (4). SLU7 depletion in HeLa nuclear extract reveals that SLU7 is required to hold exon 1 tightly within the spliceosome for attack on a prespecified AG (1,4). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SLU7 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 241-420 mapping within an internal region of SLU7 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 241-420 mapping within an internal region of SLU7 of human origin |
| Entrez Gene | 10569 |
|---|
| Application Notes | recommended for detection of SLU7 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
