| Product Name | TDP1 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Tyrosyl-DNA phosphodiesterase 1 (TDP1), a DNA repair enzyme, catalyzes the hydrolysis of phophodiester bonds between tyrosine residues and DNA 3’-phosphates. In addition, TDP1 removes glycolate from single-stranded DNA containing a 3’-phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. A unique HKD signature motif with highly conserved lysine and histidine residues present in TDP1 places the enzyme in a distinct class within the phospholipase D superfamily. The hydrolytic reaction catalyzed by TDP1 occurs by a phosphoryl transfer reaction common to all members of the PLD superfamily. Loss-of-function mutations in TDP1 may cause spinocerebellar ataxia with axonal neuropathy by interfering with DNA transcription or by inducing apoptosis in postmitotic neurons. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TDP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 309-608 mapping at the C-terminus of TDP1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 309-608 mapping at the C-terminus of TDP1 of human origin |
| Entrez Gene | 55775 |
|---|
| Application Notes | recommended for detection of TDP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
