| Product Name | β-glucuronidase Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The enzyme ∫-glucuronidase catalyzes the conversion of ∫-D-glucuronoside and water to an alcohol and D-glucuronate. Deficiency of ∫-glucuronidase is the cause of the human lysosomal storage disorder mucopolysaccharidosis type VII (MPS VII). Specifically, two residues appear important for catalytic activity: Glu 451 and Glu 540. Mutations at these sites affect the overall structure of the protein, which normally consists of a homotetramer with each promoter including a jelly roll barrel, an immunoglobulin constant domain and a TIM barrel. Regulation of ∫-glucuronidase activity may play a role in tumorigenesis and the invasiveness of a number of cancers, and is also an important factor in the development of functional prodrugs that require the cleavage of an active cytostatic by endogenous enzymes for antitumor activity. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of &beta-glucuronidase of mouse, rat and human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 352-651 mapping at the C-terminus of &beta -glucuronidase of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 352-651 mapping at the C-terminus of β-glucuronidase of human origin |
| Entrez Gene | 2990 |
|---|
| Application Notes | recommended for detection of &beta-glucuronidase of mouse, rat and human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
