| Product Name | cathepsin A Antibody (H-53) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The cathepsin family of proteolytic enzymes include several diverse classes of proteases. Cathepsins B, L, H, K, S and O comprise the cysteine protease class (1). Cathepsins D and E comprise the aspartyle protease class (2). The serine protease class includes cathepsin G (3). Cathepsins function in cellular metabolism and participate in peptide biosynthesis and protein degradation. Cathepsin A, a serine carboxypeptidase, exists in a high molecular weight lysosomal complex with b-galactosidase (b-gal) and a-neuraminidase (Neu1) (4). Cathepsin A functions to protect b-gal and Neu1 from intralysosomal proteolysis (4). Deficiencies in cathepsin A lead to deficiencies in b-gal and Neu1 (4). The gene encoding human cathepsin A maps to chromosome 20q13.12 (5). Mutations in this gene cause glactosialidosis, a lysosomal storage disorder resulting from the b-gal and Neu1 deficiencies (4). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of cathepsin A of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 181-233 mapping within an internal region of cathepsin A of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 181-233 mapping within an internal region of cathepsin A of human origin |
| Entrez Gene | 5476 |
|---|
| Application Notes | recommended for detection of cathepsin A of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
