| Product Name | Pael-R Antibody (H-250) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Pael-R (Parkin-associated endothelin receptor-like receptor), also known as GPR37 (G protein-coupled receptor 37), EDNRBL or ETBR-LP-1 (endothelin B receptor-like protein 1), is a 613 amino acid multi-pass membrane protein that belongs to the G-protein coupled receptor 1 family. Pael-R is expressed in spinal cord and brain, with lower levels found in liver, testis and placenta. When overexpressed, Pael-R causes cells to unfold and accumulate, eventually causing dopaminergic neuronal death in juvenile Parkinson disease (PDJ). Pael-R functions as an orphan receptor and also forms a complex with CHIP, HSP 70 and Parkin. The gene encoding Pael-R maps to human chromosome 7, which comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome and Williams-Beuren syndrome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Pael-R of human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 31-280 mapping within an N-terminal extracellular domain of Pael-R of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 31-280 mapping within an N-terminal extracellular domain of Pael-R of human origin |
| Entrez Gene | 2861 |
|---|
| Application Notes | recommended for detection of Pael-R of human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
