| Product Name | CCDC6 Antibody (H-160) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | CCDC6 (coiled-coil domain containing 6), also known as H4, PTC, TPC or TST1, is a 585 amino acid cytoskeletal protein. Expressed throughout the body, CCDC6 exists in an alpha helical conformation and has a leucine zipper domain through which it can fuse to PDGFR-∫ (platelet-derived growth factor receptor beta), a protein that functions as a mitogen for mesenchyme- and glia-derived cells. Additionally, CCDC6 is a fusion partner of Ret (RET receptor tyrosine kinase), a proto-oncogene that is involved in GDNF signaling. These fusion products are not present in normal cells, but are the result of a chromosomal rearrangement in the CCDC6 gene which renders the CCDC6 protein susceptible to fusion events. When CCDC6 is fused to either PDGFR-∫ or Ret, further chromosomal rearrangements may occur that can lead to various carcinomas including human papillary thyroid carcinoma, chronic myelomonocytic leukemia and mammary and cutaneous gland tumors. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CCDC6 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 111-270 mapping within an internal region of CCDC6 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 111-270 mapping within an internal region of CCDC6 of human origin |
| Entrez Gene | 8030 |
|---|
| Application Notes | recommended for detection of CCDC6 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
