| Product Name | ATAD3A/B/C Antibody (H-228) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The AAA ATPase family of molecular chaperones are characterized by a highly conserved AAA motif. Composed of 200-250 residues, the AAA domain contains Walker homology sequences and imparts ATPase activity. Members of the AAA ATPase family act as DNA helicases as well as transcription factors and are thought to be involved in several cellular functions such as cell-cycle regulation, protein proteolysis, organelle biogenesis and vesicle-mediated protein transport. Mitochondrial membrane proteins ATAD3A and ATAD3B contribute to the stabilization of nucleoids which are large mitochondrial DNA (mtDNA)-protein complexes. ATAD3A/B may participate in the transformation pathway and the chemosensitivity of oligodendrogliomas. The genes encoding ATAD3A/B/C maps to human chromosome 1, which houses over 3,000 genes and is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ATAD3A, ATAD3B and ATAD3C of human origin and ATAD3A of mouse and rat origin by WB, IP, IF and ELISA non cross-reactive with other ATAD family members | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 407-634 mapping at the C-terminus of ATAD3A of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 407-634 mapping at the C-terminus of ATAD3A of human origin |
| Entrez Gene | 55210 |
|---|
| Application Notes | recommended for detection of ATAD3A, ATAD3B and ATAD3C of human origin and ATAD3A of mouse and rat origin by WB, IP, IF and ELISA non cross-reactive with other ATAD family members |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
