Application
Western blot analysis of MESDC2 expression in non-transfected 293T: (A), mouse MESDC2 transfected 293T: (B), Jurkat (C), K-562 (D) and NIH/3T3 (E) whole cell lysates and mouse liver tissue extract (F).| Product Name | MESDC2 Antibody (D-19) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | MESDC2 (mesoderm development candidate 2), also known as BOCA or MESD, is a 234 amino acid endoplasmic reticulum protein belonging to the MESD family. Considered a chaperone protein, MESDC2 specifically assists in folding beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) through N- and C-terminal unstructured regions. MESDC2 modulates the Wnt pathway by chaperoning coreceptors LRP5 and LRP6 to the plasma membrane, and is essential for mesoderm induction and embryonic polarity. The gene encoding MESDC2 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MESDC2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with MESDC1 also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of MESDC2 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of MESDC2 of human origin |
| Entrez Gene | 23184 |
|---|
Application
Western blot analysis of MESDC2 expression in non-transfected 293T: (A), mouse MESDC2 transfected 293T: (B), Jurkat (C), K-562 (D) and NIH/3T3 (E) whole cell lysates and mouse liver tissue extract (F).| Application Notes | recommended for detection of MESDC2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with MESDC1 also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
