| Product Name | CPSF6 Antibody (H-59) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | 3' ends of eukaryotic mRNAs can undergo processing events that include endonucleolytic cleavage and polyadenylation. Cleavage and polyadenylation specificity factors (CPSF) mediate 3' cleavage of the transcript and subsequent polyadenylation. CPSF6, also known as CFIm68 (mammalian cleavage factor I, 68 kDa subunit), HPBRII-4 or HPBRII-7, is a member of the CPSF6/7 family and contains an N-terminal RNA recognition motif (RRM) and a C-terminal RS-like domain. Via its RS-like domain, CPSF6 interacts with SRp20, Tra-2∫ and 9G8. CPSF6 localizes to the paraspeckles and forms a heterodimer with NUDT21, comprising the CFIm complex which is essential for the first step in pre-mRNA 3’ cleavage and polyadenylation processing. CPSF6 is the larger subunit of the complex and is present in only half of the two heterodimer combinations (the other half being a dimer of NUDT21 and CPSF7). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CPSF6 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 167-225 mapping within an internal region of CPSF6 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 167-225 mapping within an internal region of CPSF6 of human origin |
| Entrez Gene | 11052 |
|---|
| Application Notes | recommended for detection of CPSF6 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
