| Product Name | GFRα-4 Antibody (H-71) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. Receptors for these factors include GFR?-1 (previously designated GDNFR-?), GFR?-2 (also designated RETL2), GFR?-3 and GFR?-4 (also known as persephin receptor). The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosylphosphoinositol linkage. Binding of GDNF or NTN to one of these receptors leads to the activation of the tyrosine kinase Ret. GFR?-4 mediates the activation and GDNF-induced autophosphorylation of the RET receptor. It is mainly expressed in the adult thyroid gland, but lower levels may also be detected in fetal adrenal and thyroid glands. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of mature GFR&alpha-4 and GFR&alpha-4 precursor of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 101-171 mapping within an internal region of GFR&alpha -4 precursor of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 101-171 mapping within an internal region of GFRα-4 precursor of human origin |
| Entrez Gene | 64096 |
|---|
| Application Notes | recommended for detection of mature GFR&alpha-4 and GFR&alpha-4 precursor of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
