| Product Name | ORP-1 Antibody (H-53) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Members of the oxyserol-binding protein (OSBP) family function as intracellular lipid receptors. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. ORPs (OSBP-related proteins) belong to a subfamily of OSBPs and consists of ORP-1 and ORP-2. The ORPs have a highly conserved OSBP-type sterol-binding region and a pleckstrin homology domain. They strongly bind to phosphatidic acid and weakly bind to phosphatidylinositol 3-phosphate. Three isoforms of ORP-1 are produced due to alternative splicing. Isoform ORP-1A is expressed only in retina, brain, pineal gland, fetal brain, and cultured retinal pigment epithelial cells, whereas ORP-1B is expressed ubiquitously. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ORP-1 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other ORP family members also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 898-950 mapping at the C-terminus of ORP-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 898-950 mapping at the C-terminus of ORP-1 of human origin |
| Entrez Gene | 114876 |
|---|
| Application Notes | recommended for detection of ORP-1 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other ORP family members also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
