| Modification Notes |
HATH-6, also known as atonal homolog 8 (ATOH8), is a 321 amino acid putative transcription factor. Localized to the nucleus, HATH-6 is expressed in kidney, lung, liver, pancreas, heart and the endothelium of umbilical vessels. HATH-6 is thought to participate in podocyte development in the kidney and may be involved in specification and differentiation of brain neuronal cell lineages. As a transcription factor, HATH-6 contains one basic helix-loop-helix (bHLH) domain. In order to efficiently bind to DNA, HATH-6 must be bound to another bHLH domain containing protein. HATH-6 exists as two isoforms produced by alternative splicing. |