| Product Name | Testican-3 Antibody (H-52) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The Testican family, also designated BM-40/SPARC/osteonectin, is composed of highly conserved, extracellular, calcium-binding, sulfate proteoglycans. Expression of Testicans is detected in a variety of tissues, but is most abundant in brain. Family members include Testican-1, Testican-2, Testican-3, and an amino-terminal splice variant of Testican-3, designated N-Tes. Most Testicans inhibit MT-MMPs and thereby inhibit the activity of pro-MMP-2. Testican-3 is a 436-amino acid protein that contains a follistatin-like domain, a calcium-binding domain, a COOH-terminal thyroglobulin domain, and two glycosaminoglycan attachment sites. Both Testican-3 and N-Tes are expressed in normal brain but down-regulated in glioma tissues. Transfection of either the N-Tes or Testican 3 gene into transformed glioma or kidney cells suppresses their invasive growth in collagen gel, suggesting that both N-Tes and Testican 3 interfere with tumor invasion. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Testican-3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 163-214 mapping within an internal region of Testican-3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 163-214 mapping within an internal region of Testican-3 of human origin |
| Entrez Gene | 50859 |
|---|
| Application Notes | recommended for detection of Testican-3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
