| Modification Notes |
The human ∫-glucan protein (Dectin-1) is a small, type II transmembrane receptor that enables ∫-glucan dependent, nonopsonic recognition of zymosan and other yeast-derived particles by primary macrophages. Dectin-1 is expressed in dendritic cells, and is the human homologue of the C-type (calcium dependent) lectin-like receptor (CLEC) family that plays an important role in regulating innate immunity. The CLEC protein structure has a specific fold that provides a highly static scaffold for combinatorial display of variable antigen residues. This fold differs from the classic immunoglobulin fold, illustrating an evolutionary solution for balancing diversity against stability. CLEC-6 is a single-pass, type II transmembrane protein that is highly expressed in bone marrow and spleen and weakly expressed in peripheral blood leukocytes. CLEC-6 may function as a receptor in the antigen uptake at the infection location. |
