Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and is about 3% of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation. In cases of Prader-Willi syndrome, there is a partial or complete deletion of this region from the paternal copy of chromosome 15. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of NMES1 of mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope mapping near the C-terminus of NMES1 of mouse origin
Tissue Specificity
epitope mapping near the C-terminus of NMES1 of mouse origin
Application
Application
Western blot analysis of NMES1 expression in NRK (A) and KNRK (B) whole cell lysates and rat testis tissue extract (C).
Application
Western blot analysis of NMES1 expression in KNRK whole cell lysate.
Application Notes
recommended for detection of NMES1 of mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.