| Product Name | PDE10A Antibody (H-219) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | PDE10A (phosphodiesterase 10A) is a striatum-enriched dual-substrate phosphodiesterase that participates in signal transduction by regulating the concentration of cyclic nucleotides. Localized to soluble cellular fractions within the cytoplasm, PDE10A can hydrolyze both cGMP and cAMP to the corresponding nucleoside 5-prime monophosphate, thereby eliminating cGMP- and cAMP-mediated intracellular signaling. Through its ability to hydrolyze cyclic nucleotides, PDE10A regulates the excitability of medium spiny neurons located in the striatum. PDE10A is expressed abundantly in the putamen and caudate nuclear regions of the testis and brain, with moderate expression observed in the pituitary gland, thalamus and cerebellum. PDE10A contains an N-terminal regulatory domain and a C-terminal catalytic domain which has two putative divalent metal binding sites. Two isoforms exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Phosphodiesterase 10A of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 82-300 mapping near the N-terminus of PDE10A of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 82-300 mapping near the N-terminus of PDE10A of human origin |
| Entrez Gene | 10846 |
|---|
| Application Notes | recommended for detection of Phosphodiesterase 10A of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
