| Modification Notes |
UNC93A (unc-93 homolog A), also known as HmUNC-93A, is a 457 amino acid multi-pass membrane protein and human homolog of C. elegans unc-93, a protein involved in the coordination and regulation of muscle contraction. Expressed in testis, small intestine, spleen, prostate and ovary, UNC93A is encoded by a gene located on human chromosome 6. Human chromosome 6 contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6. |