| Product Name | LCOR Antibody (H-195) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | LCOR (Ligand-dependent corepressor), also referred as MLR2, is a 433 amino acid transcriptional corepressor that contains an LXXLL motif, a nuclear localization signal and a helix-loop-helix domain. LCOR is widely expressed in fetal and adult tissues and is recruited to nuclear receptors through its LXXLL motif. LCOR interacts with several estrogen receptors, such as ERå and ER∫ in the presence of estradiol. Additionally, LCOR acts as a molecular scaffold, functioning to recruit proteins involved in transcriptional repression to the DNA. LCOR activity is inhibited in a receptor-dependent fashion by the HDAC (histone deacetylase) inhibitor trichostatin A, suggesting HDAC-dependent mode of action. LCOR functions in a negative feedback loop to reduce hormone-induced transactivation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of LCOR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 87-281 mapping within an internal region of LCOR of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 87-281 mapping within an internal region of LCOR of human origin |
| Application Notes | recommended for detection of LCOR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
