| Modification Notes |
INOC1, also known as INO80 or hINO80, is a 1,556 amino acid nuclear protein that contains one DBINO domain, one helicase ATP-binding domain and one helicase C-terminal domain. Expressed in a variety of tissues, including liver, brain and pancreas, INOC1 functions as a component of the INO80 chromatin remodeling complex where it acts as a putative DNA helicase that binds DNA and exhibits DNA-dependent ATPase activity. The gene encoding INOC1 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes. |