| Product Name | Angiotensinase C Antibody (H-155) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Angiotensinase C, also designated lysosomal Pro-X carboxypeptidase or prolylcarboxypeptidase, belongs to the peptidase S28 family. Angiotensinase C which is highly expressed in placenta, lung and liver and is also expressed in heart, pancreas, kidney and brain, is a cell matrix-associated prekalli-krein (PK) activator. Angiotensin II, a substrate of Angiotensinase C, is involved in regulating blood pressure and electrolyte balance, suggesting that the gene encoding for Angiotensinase C may be related to essential hypertension, a condition involving high blood pressure with no known cause. Angiotensinase C cleaves off the C-terminal amino acids linked to proline in peptides such as Angiotensin II, III and des-Arg9-bradykinin. The cleavage occurs at an acidic pH, but with some substrates enzymatic activity is retained at a neutral pH. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Angiotensinase C of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 206-360 mapping within an internal region of Angiotensinase C of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 206-360 mapping within an internal region of Angiotensinase C of human origin |
| Application Notes | recommended for detection of Angiotensinase C of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
