| Product Name | ARHGAP29 Antibody (M-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in down regulation of their active form. ARHGAP29 (Rho GTPase activating protein 29), also known as PARG1, is a 1,261 amino acid protein that is widely expressed and contains a phorbol-ester/DAG-type zinc finger and a Rho-GAP domain. There is high expression of ARHGAP29 in skeletal muscle and heart, intermediate expression in placenta, liver and pancreas, and weak expression in brain, lung and kidney. As a GTPase activator, ARHGAP29 converts Rho-type GTPases to an inactive GDP-bound state and has strong activity toward Rho A, and weaker activity toward Rac 1 and Cdc42. Also considered a specific effector of Rap 2A to regulate Rho, ARHGAP29 is strongly down-regulated in mantle-cell lymphomas and up-regulated in migrating glioma cells. ARHGAP29 exists as two alternatively spliced isoforms. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ARHGAP29 of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 881-1180 mapping within an internal region of ARHGAP29 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 881-1180 mapping within an internal region of ARHGAP29 of mouse origin |
| Application Notes | recommended for detection of ARHGAP29 of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
