| Product Name | FBL5 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | FBL5 is a 691 amino acid protein encoded by the human gene FBXL5. FBL5 contains one 40 amino acid F-box region, making it a member of the F-box family. FBL5 also contains four LRR (leucine-rich) repeats. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. F-box proteins are members of a large family that regulates cell cycle, immune response, signalling cascades and developmental programs by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Localized near the nucleus in the cytoplasm, FBL5 is ubiquitously expressed and believed to recognize and bind to phosphorylated proteins to promote their ubiquitination and degradation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of FBL5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-300 mapping at the N-terminus of FBL5 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-300 mapping at the N-terminus of FBL5 of human origin |
| Entrez Gene | 26234 |
|---|
| Application Notes | recommended for detection of FBL5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
