| Modification Notes |
Scotin (Protein shisha-5), also known as Putative NF-kappa-B-activating protein 120, is a 240 amino acid single-pass type I membrane protein that localizes to the endoplasmic reticulum and nucleus. Scotin belongs to the shisha protein family and contains a proline-rich domain. Both caspase-dependent and p53/TP53-dependent apoptosis appear to be induced by Scotin. Scotin is abundant in murine spleen and thymus tissue. The gene encoding Scotin maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. |
