| Modification Notes |
DC-LAMP (DC-lysosome-associated membrane glycoprotein), also known as LAMP-3 (Lysosomal-associated membrane protein 3), TSC403 or CD208, is a 416 amino acid lysosome membrane protein that belongs to the LAMP family. DC-LAMP is expressed in lung, lymphoid organs and dendritic cells and is upregulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues. It is suggested that DC-LAMP may be responsible for changing lysosomal function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells. DC-LAMP is thought to play an important part in enhancing metastasic potential and may be a prognostic factor for cervical cancer. |