| Product Name | Cytokeratin 3 Antibody (H-99) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. The Cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also useful markers in identifying the origin of metastatic tumors. There are two types of Cytokeratins: types I and II. Type I Cytokeratins are acidic proteins, whereas type II Cytokeratins are neutral or basic proteins. Cytokeratin 3 is a type II Cytokeratin expressed in the corneal epithelium along with Cytokeratin 12. Dominant-negative mutations in the Cytokeratin 3 and Cytokeratin 12 genes cause Meesmann corneal dystrophy (MCD), an autosomal dominant disease that is characterized by weakness of the anterior corneal epithelium. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Cytokeratin 3 of human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 581-629 mapping at the C-terminus of Cytokeratin 3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 581-629 mapping at the C-terminus of Cytokeratin 3 of human origin |
| Entrez Gene | 3850 |
|---|
| Application Notes | recommended for detection of Cytokeratin 3 of human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
