| Product Name | KLF8 Antibody (H-103) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The Krüppel-type zinc finger transcription factors comprise a conserved family of DNA binding proteins that are important in developmental regulation. The Krüppel zinc finger transcription factor was initially identified in Drosophila as a segmentation gene. Krüppel-like factor 8 (KLF8), also called basic Krüppel-like factor 3 and zinc finger protein 741, is a 359 amino acid transcriptional repressor that binds CACCC elements in DNA and activates or represses their target genes in a context-dependent manner. KLF8 is expressed ubiquitously in the nucleus of many cell types and its expression is elevated in several human cancers. KLF8 is post-translationally modified and negatively regulated by sumoylation via SUMO-1, SUMO-2 or SUMO-3. Mutation of the sumoylation site, Lysine 67, to Arginine 67 enhances the ability of KLF8 to repress or activate its target promoters. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of KLF8 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 183-285 mapping within an internal region of KLF8 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 183-285 mapping within an internal region of KLF8 of human origin |
| Entrez Gene | 11279 |
|---|
| Application Notes | recommended for detection of KLF8 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
