| Product Name | ANKRD11 Antibody (H-237) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | ANKRD11 (Ankyrin repeat domain-containing protein 11, Ankyrin repeat-containing cofactor 1) is a 2,664 amino acid protein encoded by the human gene ANKRD11. This nuclear protein belongs to a novel family of ankyrin repeat-containing cofactors for p160 nuclear receptor coactivators and contains four Ankyrin repeats. Members of the p160 nuclear receptor coactivators interact with liganded nuclear receptors to enhance transcription of target genes. ANKRD11 has two intrinsic repression domains (RD): an N-terminal RD1 at residues 318-611 and a C-terminal RD2 at 2369-2663. ANKRD11 also contains an activation domain (AD) capable of stimulating transcription in vitro. The minimal AD is delimited to a 70-amino acid region at residues 2076-2145. Overall, ANKRD11 acts as a transcriptional repressor, suggesting that RD domains may suppress the AD activity. ANKRD11 shows the potential of modulating a combination of repression and activation signals. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ANKRD11 of mouse, rat and human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1545-1778 mapping within an internal region of ANKRD11 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1545-1778 mapping within an internal region of ANKRD11 of human origin |
| Entrez Gene | 29123 |
|---|
| Application Notes | recommended for detection of ANKRD11 of mouse, rat and human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
