| Product Name | Otoferlin Antibody (H-150) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Otoferlin is a single-pass type II membrane protein composed of 1,230 amino acid residues. Otoferlin exists in four isoforms; isoform 1 is the full-length Otoferlin protein, whereas isoforms 2-4 are shorter versions of the protein. Expression of isoforms 1 and 3 is demonstrated in adult brain, while isoform 2 is expressed in the fetus, adult brain, heart, placenta, skeletal muscle and kidney tissues. Otoferlin has three C2 domains and a single carboxy-terminal transmembrane domain. The Otoferlin gene, OTOF, and its surrounding genes map to 2p23-p22, and the 5’ region of OTOF is centromeric. Mutations in the OTOF gene are implicated in deafness. Otoferlin is homologous to the C. elegans spermatogenesis factor FER-1 and to human dysferlin, implicating the involvement of Otoferlin in the Ca2+-triggered synaptic vesicle-plasma membrane fusion. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Otoferlin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 691-840 mapping within an internal region of Otoferlin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 691-840 mapping within an internal region of Otoferlin of human origin |
| Entrez Gene | 9381 |
|---|
| Application Notes | recommended for detection of Otoferlin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
