Application
Western blot analysis of ASB-9 expression in non-transfected: (A) and human ASB-9 transfected: (B) 293T whole cell lysates.| Product Name | ASB-9 Antibody (H-70) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B and C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. Members of the ASB family include ASB-1 through ASB-18 and are involved in a variety of biological processes. ASB-9 is a 294 amino acid member of this family. It contains six ankyrin repeats and one SOCS box domain. ASB-9 functions as a ubiquitin ligase and, via its SOCS box domain, it specifically interacts with creatine kinase-B, targeting it for degradation and regulating its expression within the cell. Two isoforms exist for ASB-9 due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ASB-9 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-70 mapping at the N-terminus of ASB-9 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-70 mapping at the N-terminus of ASB-9 of human origin |
| Entrez Gene | 140462 |
|---|
Application
Western blot analysis of ASB-9 expression in non-transfected: (A) and human ASB-9 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of ASB-9 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
