Application
Western blot analysis of DMRT1 expression in HS 181.Tes whole cell lysate.| Product Name | DMRT1 Antibody (H-240) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | DMRT1(Doublesex- and mab-3-related transcription factor 1), also known as DMT1 or DM domain expressed in testis protein 1, is a 373 amino acid protein that contains a highly conserved zinc finger-like DNA-binding motif (DM domain). The DMRT genes encode a large family of transcription factors that participate in the sexual development of vertebrates and invertebrates. In humans, DMRT1 is expressed only in testis and is transported to the nucleus by karyopherin ∫1. DMRT1 is required for testis development and may be involved in the formation of the seminiferous tubules. The gene encoding DMRT1 exhibits a gonad-specific and sexually dimorphic expression pattern during embryogenesis in mammals and birds. Hemizygosity of the DMRT1 gene results in abnormal testicular development and XY feminization. DMRT1 is expressedas four isoforms due to alternative splicing. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of DMRT1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 134-373 mapping at the C-terminus of DMRT1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 134-373 mapping at the C-terminus of DMRT1 of human origin |
| Entrez Gene | 1761 |
|---|
Application
Western blot analysis of DMRT1 expression in HS 181.Tes whole cell lysate.| Application Notes | recommended for detection of DMRT1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
